Phenotype Image Detail

Image

Caption

Electron micrographs of rough endoplasmic reticulum (A) and Golgi apparatus (B and C) of visceral yolk sac endoderm of wild-type (A and B) and Apob^tm3Sgy/Apob^tm3Sgy (C) embryos at 9.5 days. In A and B, arrowheads point to individual lipoprotein particles, occurring singly and in rows within the lumen of the rough endoplasmic reticulum. Most of these particles measure 300-800 angstroms (A) in diameter, the size range of VLDL. Arrows point to individual lipoproteins (also 300-800 A in diameter) in forming secretory vesicles of the Golgi apparatus (B) in wild-type epithelium. Both the rough endoplasmic reticulum and the Golgi apparatus of mutant embryos completely lacked lipid staining particles of VLDL size as detected by lipid staining (C). In addition, the Golgi apparatus of mutant visceral endodermal cells often appeared to be diminished in amount owing to the absence of lipoprotein particle content (compare B and C). Magnification, 48,000 x.

Copyright

This image is from Farese RV Jr, J Lipid Res 1996 Feb;37(2):347-60 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text is from JLR. J:84977

Associated Alleles

Symbol	Name
Apob^tm3Sgy	apolipoprotein B; targeted mutation 3, Stephen G Young

Associated Genotypes

Allelic Composition	Genetic Background
Apob^tm3Sgy/Apob^tm3Sgy	involves: 129S7/SvEvBrd * C57BL/6