Phenotype Image Detail

Image

Caption

Ym1 crystal location in the Ncf1^tm1Hbd/Ncf1^tm1Hbd mouse. Dorsal view of lungs from 10 month old wild-type (A) and Ncf1^tm1Hbd/Ncf1^tm1Hbd (B) mice. The pale areas at the periphery of B are sites of consolidation with a chronic inflammatory cell infiltrate composed predominantly of macrophages surrounding crystals. C: Electron micrograph of the mutant mouse lung shows intracytoplasmic, needle-shaped crystals within alveolar macrophages (D). A 6-month old mutant mouse with chronic liver and skin abscesses had crystals within the bile ducts (E) and adjacent to bacteria in the skin (F).

Copyright

This image is from Harbord M, J Biol Chem 2002 Feb 15;277(7):5468-75 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:74593

Associated Alleles

Symbol	Name
Ncf1^tm1Hbd	neutrophil cytosolic factor 1; targeted mutation 1, Marcus Harbord

Associated Genotypes

Allelic Composition	Genetic Background
Ncf1^tm1Hbd/Ncf1^tm1Hbd	involves: 129