Phenotype Image Detail

Image

Caption

Phenotypes observed in Asph^tm1Jed/Asph^tm1Jed mice. A: A shortened snout is observed in Asph^tm1Jed/Asph^tm1Jed (-/-) mice with complete penetrance but variable expressivity. B: A mild defect in the palatal ridges (arrowheads) was observed in all mutant mice examined. C: Fusion of the digits (soft tissues only) was observed to varying degrees in forelimbs and hindlimbs of mutant mice with essentially complete penetrance. Hindpaws from wild-type (+/+) and mutant mice are pictured.

Copyright

This image is from Dinchuk JE, J Biol Chem 2002 Apr 12;277(15):12970-7 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:75888

Associated Alleles

Symbol	Name
Asph^tm1Jed	aspartate-beta-hydroxylase; targeted mutation 1, Joe E Dinchuk

Associated Genotypes

Allelic Composition	Genetic Background
Asph^tm1Jed/Asph^tm1Jed	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J
Asph^tm1Jed/Asph^tm1Jed	involves: 129S6/SvEvTac * 129S7/SvEvBrd