Phenotype Image Detail

Image

Caption

Histological examination of neural tube sections. A and B: Transverse sections at the hindlimb level show the expansion of the neural tube in a Prkaca^tm1Gsm/Prkaca⁺ Prkacb^tm1Gsm/Prkacb^tm1Gsm or Prkaca^tm1Gsm/Prkaca^tm1Gsm Prkacb^tm1Gsm/Prkacb⁺ embryo (PKA-deficient) (B) compared with the wild-type (WT, A) at E10.5. C and D: Longitudinal sections through the dorsal half of the neural tube reveal the apparent hyperplasia in the mutant neuroepithelium (D) compared with the wild-type (C) at E10.5. Note the appearance of dorsal root ganglia (DRG, arrows) along the mutant neural tube (D). E and F: transverse sections at the lumbar region of wild-type (E) and mutant embryos (F) at E12.5. Note the dramatic expansion and the abnormal neuroepithelium in the mutant neural tube and the regression of DRG (F). DRG in wild-type is shown in E (arrow).

Copyright

This image is from Huang Y, J Biol Chem 2002 May 31;277(22):19889-96 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:76765

Associated Alleles

Symbol	Name
Prkaca^tm1Gsm	protein kinase, cAMP dependent, catalytic, alpha; targeted mutation 1, G Stanley McKnight
Prkacb^tm1Gsm	protein kinase, cAMP dependent, catalytic, beta; targeted mutation 1, G Stanley McKnight

Associated Genotypes

Allelic Composition	Genetic Background
Prkaca^tm1Gsm/Prkaca^+ Prkacb^tm1Gsm/Prkacb^tm1Gsm	involves: 129X1/SvJ * C57BL/6
Prkaca^tm1Gsm/Prkaca^tm1Gsm Prkacb^tm1Gsm/Prkacb^+	involves: 129X1/SvJ * C57BL/6