Phenotype Image Detail

Image

Caption

Development of cataract in Pcbd1^tm1Grc/Pcbd1^tm1Grc mice. A: Pcbd1^tm1Grc/Pcbd1^tm1Grc (DCoH -/-) mouse showing unilateral lens opacity. B: Plot displaying the frequency of first visual observation of cataract in mutant mice in age intervals up to 1 year. C: Section of a mutant mouse with posterior cortical cataract (right) and a Pcbd1^tm1Grc/Pcbd1⁺ mouse of similar age with a healthy eye (left). Transverse sections of paraffin-embedded tissue were stained with hematoxylin and eosin. Note the vacuoles visible in the iris and the Morgagnian granules of degraded and fluid filled lens tissue underlying the posterior capsule.

Copyright

This image is from Bayle JH, J Biol Chem 2002 Aug 9;277(32):28884-91 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:78257

Associated Alleles

Symbol	Name
Pcbd1^tm1Grc	pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1; targeted mutation 1, Gerald R Crabtree

Associated Genotypes

Allelic Composition	Genetic Background
Pcbd1^tm1Grc/Pcbd1^tm1Grc	either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)