Phenotype Image Detail

Image

Caption

Histological changes in the spleen of Sirpa^tm1Nog/Sirpa^tm1Nog mice. The spleen was removed from 11-week old wild-type (+/+, left panels) or Sirpa^tm1Nog/Sirpa^tm1Nog (-/-, right panels) mice, fixed, and stained with Mayer's hematoxylin-eosin. Sections were examined with a light microscope equipped with phase-contrast optics, and megakaryocytes are indicated by arrowheads. Data are representative of three independent experiments. Original magnification: x100 (upper panels) or x400 (lower panels).

Copyright

This image is from Yamao T, J Biol Chem 2002 Oct 18;277(42):39833-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:79592

Associated Alleles

Symbol	Name
Sirpa^tm1Nog	signal-regulatory protein alpha; targeted mutation 1, Tetsuya Noguchi

Associated Genotypes

Allelic Composition	Genetic Background
Sirpa^tm1Nog/Sirpa^tm1Nog	involves: 129P2/OlaHsd * C57BL/6