Phenotype Image Detail

Image

Caption

A and B: Mouse embryos at 10.5 dpc. All Ncoa6^tm1Jxu/Ncoa6^tm1Jxu (-/-) embryos are smaller than wild-type (+/+) and Ncoa6^tm1Jxu/Ncoa6⁺ embryos at this stage. Large blood pool in hearts (*) and pericardial effusion (arrow) were found in some mutant embryos (B). C and D: Cross-sections of hearts showing abnormal mutant heart morphologies, including the thin ventricular wall (arrows) and detachment of the endocardium (*).

Copyright

This image is from Kuang SQ, J Biol Chem 2002 Nov 22;277(47):45356-60 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:80175

Associated Alleles

Symbol	Name
Ncoa6^tm1Jxu	nuclear receptor coactivator 6; targeted mutation 1, Jianming Xu

Associated Genotypes

Allelic Composition	Genetic Background
Ncoa6^tm1Jxu/Ncoa6^tm1Jxu	involves: 129S6/SvEvTac * C57BL/6