Phenotype Image Detail

Image

Caption

Frozen sections of the kidneys isolated from wild-type (A) and Lgmn^tm1Ihn/Lgmn^tm1Ihn (B) mice were subjected to immunofluorescent microscopy with anti-lamp-2 antibody. Arrowheads indicate enlarged structures found in the mutant mice. Asterisks mark the lumen of proximal tubule. Bars=5 um. C and D: Electron microscopic images of the proximal tubule cells of mutant mice. Arrowheads indicate the large and aberrant lysosomes containing electron-dense and/or membranous materials. BB, brush border; BL, basal lamina; Mt, mitochondrion. Bars = 1 um.

Copyright

This image is from Shirahama-Noda K, J Biol Chem 2003 Aug 29;278(35):33194-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:85207

Associated Alleles

Symbol	Name
Lgmn^tm1Ihn	legumain; targeted mutation 1, Ikuko Hara-Nishimura

Associated Genotypes

Allelic Composition	Genetic Background
Lgmn^tm1Ihn/Lgmn^tm1Ihn	involves: 129P2/OlaHsd * C57BL/6J