Phenotype Image Detail

Image

Caption

Abnormal development of Nfe2l1^tm1Ywk/Nfe2l1^tm1Ywk Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk embryos. A: E10.5 Nfe2l1^tm1Ywk/Nfe2l1^tm1Ywk Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk embryos are small and developmentally delayed. Photographs were taken immediately after dissection of littermates harvested from Nfe2l2^tm1Ywk/Nfe2l2⁺ Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk intercrossing, and embryos were determined alive by the presence of a heartbeat. Shown is histologic analysis of E10.5 compound mutant embryos showing features of apoptosis observed in the fascial ganglion (b), developing brain (c), and neural tube (d). TUNEL stain of a control embryo (e) is compared with compound mutant embryos (f and g) showing extensive apoptosis.

Copyright

This image is from Leung L, J Biol Chem 2003 Nov 28;278(48):48021-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:86725

Associated Alleles

Symbol	Name
Nfe2l1^tm1Ywk	nuclear factor, erythroid derived 2,-like 1; targeted mutation 1, Yuet Wai Kan
Nfe2l2^tm1Ywk	nuclear factor, erythroid derived 2, like 2; targeted mutation 1, Yuet Wai Kan

Associated Genotypes

Allelic Composition	Genetic Background
Nfe2l1^tm1Ywk/Nfe2l1^tm1Ywk Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk	involves: 129X1/SvJ