Phenotype Image Detail

Image

Caption

A and B, electron micrographs showing typical ultrastructures of the sarcoplasmic reticulum (SR) in wild-type (A) or Srl^tm1Hta/Srl^tm1Hta muscle (B). Wild-type muscle predominantly contained a well organized tubular SR network, whereas fenestrated plate structures were often observed in mutant muscle. Scale bar, 0.5 um. In statistical analysis (C), three wild-type mice (total 132 SR structures) and four mutant mice (144 structures) were examined, and the data indicate the means +/- S.D. Significant differences were observed in the appearance of tubular SR and fenestrated SR between the genotypes. **, p < 0.01 in t test.

Copyright

This image is from Yoshida M, J Biol Chem 2005 Feb 4;280(5):3500-6 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:96983

Associated Alleles

Symbol	Name
Srl^tm1Hta	sarcalumenin; targeted mutation 1, Hiroshi Takeshima

Associated Genotypes

Allelic Composition	Genetic Background
Srl^tm1Hta/Srl^tm1Hta	involves: 129S4/SvJae * C57BL/6J