Phenotype Image Detail

Image

Caption

A: Exemplar electron micrographs showing parietal cells from wild-type (+/+), Kcne2^tm1Gwab/Kcne2⁺ (-/+) and Kcne2^tm1Gwab/Kcne2^tm1Gwab (-/-) mice as indicated. Asterisks indicate canaliculi, which are highly distended in the case of homozygous mutant mice. Mitochondria, labeled m, are pushed to the periphery of the cell in homozygous mutant mice. Scale bars (top right), 2 um. B: Exemplar electron micrographs showing chief cells from wild-type and mutant mice. Asterisks indicate secretory vesicles, which are similar in the cells from either genotype. Scale bars (top right), 2 um.

Copyright

This image is from Roepke TK, J Biol Chem 2006 Aug 18;281(33):23740-7 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:116518

Associated Alleles

Symbol	Name
Kcne2^tm1Gwab	potassium voltage-gated channel, Isk-related subfamily, gene 2; targeted mutation 1, Geoffrey W Abbott

Associated Genotypes

Allelic Composition	Genetic Background
Kcne2^tm1Gwab/Kcne2^tm1Gwab	involves: 129S4/SvJae * C57BL/6