Phenotype Image Detail

Image

Caption

A, histological profile of sagittal sections at E10.5 showing exencephaly and defective development of cephalic area in Ybx1^tm1Tuch/Ybx1^tm1Tuch (YB1-/-) embryos. hb, hindbrain; mb, midbrain; ne, neuroepithelium. Scale bar = 1 mm. B, histological profile of whole E11.5-13.5 embryo frontal sections stained with hematoxylin and eosin staining showing severe disturbance of cephalic area in exencephalic embryos. Mutants exhibit open neural tubes. Scale bar = 200 um. C, cross-sections of wild-type (YB1+/+) and mutant E12.5 to E13.5 mouse embryos showing defective neural tube closure. Mutant mouse embryos were surrounded by the everted neuroectoderm of the midbrain and hindbrain. 3rdV, third ventricle; LV, lateral ventricle; mv, mesencephalic vesicle; po, pons. Scale bar = 1 mm. D, sagittal sections of wild-type and mutant E14.5 to E15.5 mouse embryos showing defective neural tube closure and exencephalic phenotype of the mutant embryo (upper right panel). Some mutant embryos (bottom center panels) exhibit anterior brain structure, skull closure, and size comparable with wild-type littermates. ms, mesencephalon; me, medulla; te, telencephalon; di, diencephalon; sp, spinal cord. Scale bar = 1 mm. E, sagittal sections of wild-type and mutant E14.5 to E15.5 mouse embryos showing smaller liver size of the mutant embryo (right panel). Erythrocytes (arrow) are present in wild-type liver region, but not in mutant liver (lower panel).

Copyright

This image is from Uchiumi T, J Biol Chem 2006 Dec 29;281(52):40440-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:117725

Associated Alleles

Symbol	Name
Ybx1^tm1Tuch	Y box protein 1; targeted mutation 1, Takeshi Uchiumi

Associated Genotypes

Allelic Composition	Genetic Background
Ybx1^tm1Tuch/Ybx1^tm1Tuch	involves: 129S/SvEv * C57BL/6