Phenotype Image Detail

Image

Caption

Growth retardation of Hs6st1^tm1Kkm/Hs6st1^tm1Kkm mice. The skeletal samples of newborn wild-type (+/+) and Hs6st1^tm1Kkm/Hs6st1^tm1Kkm (-/-) mice were stained with Alcian blue and arizarin red. On the whole, the skeletons of the mutant mice (B and C) were smaller than those of the wild-type mice (A). They often lacked a hind limb phalange and either possessed a smaller tarsus in the hind limb compared with the tarsus in wild-type mice or were completely lacking a tarsus. D-F, higher magnification of the respective hind limbs shown in A-C. Abnormal eye morphology was observed in approximately one-half of the mutant mice. The arrows indicate the tarsus (t), phalanges (p), and eyes (e).

Copyright

This image is from Habuchi H, J Biol Chem 2007 May 25;282(21):15578-88 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:122656

Associated Alleles

Symbol	Name
Hs6st1^tm1Kkm	heparan sulfate 6-O-sulfotransferase 1; targeted mutation 1, Koji Kimata

Associated Genotypes

Allelic Composition	Genetic Background
Hs6st1^tm1Kkm/Hs6st1^tm1Kkm	involves: 129P2/OlaHsd * C57BL/6