Phenotype Image Detail

Image

Caption

Lungs were fixed via trachea with 4% paraformaldehyde under a constant pressure of 20 cm H2O. Paraffin sections from 7 day old mice (A and B) and adult mice (C and D) were stained with hematoxylin and eosin. A, Hs6st1^tm1Kkm/Hs6st1⁺ (+/-); C, wild-type (+/+) mice. B and D, Hs6st1^tm1Kkm/Hs6st1^tm1Kkm (-/-) mice. Shown are the results at x100 magnification. The lungs of the mutant mice had apparently enlarged alveoli. E and F, the intra-alveolar distance of the lungs from 7 day old (E) and adult mice (F) was measured as the mean linear intercept (MLI). MLI was increased in the mutant mice compared with the wild-type mice. (*,p<0.001; **,p,0.001).

Copyright

This image is from Habuchi H, J Biol Chem 2007 May 25;282(21):15578-88 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:122656

Associated Alleles

Symbol	Name
Hs6st1^tm1Kkm	heparan sulfate 6-O-sulfotransferase 1; targeted mutation 1, Koji Kimata

Associated Genotypes

Allelic Composition	Genetic Background
Hs6st1^tm1Kkm/Hs6st1^tm1Kkm	involves: 129P2/OlaHsd * C57BL/6