Phenotype Image Detail

Image

Caption

Phenotype of S1pr2^tm1Rlp/S1pr2^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp mice. A: Characteristic head tilt of a 3 month old S1pr2^tm1Rlp/S1pr2^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp (S1P2; S1P3 Null) mouse. B-D, histological sections of inner ears from 6 month old mice demonstrating the absence of spiral ganglion neurons in double mutant and S1pr2^tm1Rlp/S1pr2^tm1Rlp (S1P2 Null) mice (arrows) but not in the S1pr3^tm1Rlp/S1pr3^tm1Rlp (S1P3 Null) mouse. Scale bar in B is 100 um and applies to C and D also.

Copyright

This image is from Kono M, J Biol Chem 2007 Apr;282(14):10690-6 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:121165

Associated Alleles

Symbol	Name
S1pr2^tm1Rlp	sphingosine-1-phosphate receptor 2; targeted mutation 1, Richard L Proia
S1pr3^tm1Rlp	sphingosine-1-phosphate receptor 3; targeted mutation 1, Richard L Proia

Associated Genotypes

Allelic Composition	Genetic Background
S1pr3^tm1Rlp/S1pr3^tm1Rlp S1pr2^tm1Rlp/S1pr2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6
S1pr2^tm1Rlp/S1pr2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6