Phenotype Image Detail

Image

Caption

Lats2^tm1Noj/Lats2^tm1Noj embryos exhibit severe nervous system developmental defects. A-H: Histological analyses of E13.5 embryos obtained from heterozygous intercrosses. Hematoxylin and eosin stained sections from wild-type (Lats2^+/+) and Lats2^tm1Noj/Lats2^tm1Noj (Lats2^-/-) whole embryos (A and B), hearts (C and D), neuroepithelium of the fourth ventricles (E and F), and spinal cords (G and H). I-N: Hematoxylin and eosin stained sections of hearts (I-L) and neuroepithelia of the fourth ventricle (M and N), from wild-type and mutant embryos at E10.5. I and J indicate lower magnification. O and P, TUNEL assay of spinal cord sections from wild-type and mutant embryos at E13.5. Embryo sections were stained with propidium iodide (PI, red) and Fluorescein-12-dUTP (green); merged yellow signals reflect TUNEL-positive apoptotic cells. a, atrium; bv, brain ventricle; ec, endocardiac cushion; sc, spinal cord; v, ventricle.

Copyright

This image is from Yabuta N, J Biol Chem 2007 Jun 29;282(26):19259-71 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:123480

Associated Alleles

Symbol	Name
Lats2^tm1Noj	large tumor suppressor 2; targeted mutation 1, Hiroshi Nojima

Associated Genotypes

Allelic Composition	Genetic Background
Lats2^tm1Noj/Lats2^tm1Noj	involves: 129S2/SvPas * C57BL/6