Phenotype Image Detail

Image

Caption

Analysis of neural tube closure. A: Wild-type (+/+) and Atp2c1^tm1Ges/Atp2c1^tm1Ges (-/-) embryos from the same litter at ED 10.5. The neural tube (white arrows) is closed in the wild-type but open in the mutant. Note the appearance of the neuroectoderm in the area of the rhombencephalon, which is ruffled in the mutant (red arrow). B: Hematoxylin & eosin stained sections of wild-type and mutant embryos at ED 9.5, fixed in utero. The neural tube is closed in the wild-type and open in the mutant, which also exhibits ruffling of the neuroectoderm (red arrow). N, neuroectoderm; M, mesenchyme. Bar, 100 um.

Copyright

This image is from Okunade GW, J Biol Chem 2007 Sep 7;282(36):26517-27 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:124662

Associated Alleles

Symbol	Name
Atp2c1^tm1Ges	ATPase, Ca++-sequestering; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Atp2c1^tm1Ges/Atp2c1^tm1Ges	involves: 129X1/SvJ * Black Swiss