Phenotype Image Detail

Image

Caption

Morphological evidence of Golgi and Endoplasmic reticulum stress in Atp2c1^tm1Ges/Atp2c1^tm1Ges embryos. Electron micrographs of representative wild-type (+/+, left) and Atp2c1^tm1Ges/Atp2c1^tm1Ges (-/-, right) cells illustrating differences in the Golgi and ER (endoplasmic reticulum) that occurred in the two genotypes. Highly ordered and closely stacked leaflets of the central lamellae of the Golgi apparatus (bracket and white arrow) were common in wild-type embryos but tended to be dilated, less well organized, and more difficult to identlfy in mutant embryos. RER (rough endoplasmic reticulum, black arrows) was often dilated in mutant cells and had reduced numbers of ribosomes. Dense granules (white arrowhead) were more common in mutant cells and were increased in numbers on the cis-side of the Golgi. Mitochondria (M) did not show evidence of change. N, nuclei. Bar, 1 um.

Copyright

This image is from Okunade GW, J Biol Chem 2007 Sep 7;282(36):26517-27 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:124662

Associated Alleles

Symbol	Name
Atp2c1^tm1Ges	ATPase, Ca++-sequestering; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Atp2c1^tm1Ges/Atp2c1^tm1Ges	involves: 129X1/SvJ * Black Swiss