Phenotype Image Detail

Image

Caption

Transverse histological samples of E14.5 fetuses visualized by hematoxylin and eosin staining. A, model of a normal heart. The figure was adapted from The Cove Point Foundation (Johns Hopkins University) (top left). Transverse serial sections (running left to right in sequence) of a wild-type heart with flow of blood from aorta to left ventricle and pulmonary artery to right ventricle (top middle). Arrows following the flow of blood are depicted for the first picture of every row. Penetrance of DORV (double outlet right ventricle) in wild-type animals (top right). B, VSD (ventricular septal defect) in Aip^tm1Bra/Aip^tm1Bra (Ara9^-/-) fetuses in comparison to wild-type littermate. Model of a heart with DORV (bottom left). Transverse serial sections (running left to right in sequence) of a null heart with flow of blood from both aorta and pulmonary artery into the right ventricle. Arrows following the flow of blood are depicted for the first picture of every row (bottom middle). Penetrance of DORV in mutant mice (bottom). Legend: RA, right atria; LA, left atria; RV, right ventricle; LV, left ventricle; A, aorta, PA, pulmonary artery.

Copyright

This image is from Lin BC, J Biol Chem 2007 Dec 7;282(49):35924-32 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:141575

Associated Alleles

Symbol	Name
Aip^tm1Bra	aryl-hydrocarbon receptor-interacting protein; targeted mutation 1, Christopher A Bradfield

Associated Genotypes

Allelic Composition	Genetic Background
Aip^tm1Bra/Aip^tm1Bra	involves: 129S4/SvJaeSor * C57BL/6