Phenotype Image Detail

Image

Caption

Transverse histological samples of E14.5 fetuses visualized by hematoxylin and eosin staining. A, model of a normal heart, figure adapted from The Cove Point Foundation (Johns Hopkins University) (top left). Transverse section of wild-type and heterozygote heart with normal septation between right and left ventricles (top middle). Normal septation is indicated by red arrow. Penetrance of VSD (ventricular septal defect) in wild-type mice (top right). B, VSD in Aip^tm1Bra/Aip^tm1Brafetuses in comparison to wild-type and heterozygote littermates. Model of heart with VSD (bottom left). Transverse section of homozygote hearts with opening between right and left ventricles. Abnormal septation is indicated by red arrow (bottom middle). Penetrance of VSD in homozygous mutant mice (bottom right). Legend: RA, right atria; LA, left atria; RV, right ventricle; LV, left ventricle; A, aorta; PA, pulmonary artery.

Copyright

This image is from Lin BC, J Biol Chem 2007 Dec 7;282(49):35924-32 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:141575

Associated Alleles

Symbol	Name
Aip^tm1Bra	aryl-hydrocarbon receptor-interacting protein; targeted mutation 1, Christopher A Bradfield

Associated Genotypes

Allelic Composition	Genetic Background
Aip^tm1Bra/Aip^tm1Bra	involves: 129S4/SvJaeSor * C57BL/6