Phenotype Image Detail

Image

Caption

Autoimmune symptoms of Tg(H2-K-DUSP5)21Wjl/0 mice. Tg(H2-K-DUSP5)21Wjl/0 mice develop skin lesions within areas of alopecia (A) and show increased plasma lgG1 anti-DNA antibody levels (B), as well as morphologic changes of skin (C and D) and kidney glomeruli (E and F) (indicated by white arrows). C, wild-type mouse skin (original magnification: x40). Tg(H2-K-DUSP5)21Wjl/0 mouse skin shows ulcerative dermatitis with lesion (black arrow), inflammatory cell infiltration (hatched arrow), and adjacent epithelium hyperplasia (gray arrow). E, wild type mouse kidney glomeruli appear very vascular, and glomerular capillaries contain many erythrocytes (red-stained cells without purple-stained nuclei) (original magnification: x400). F, Tg(H2-K-DUSP5)21Wjl/0 mice with skin abnormalities also exhibit advanced kidney glomerular lesions. Glomerular capillaries contain lower numbers of erythrocytes and display abundant infiltrates (pink-stained material).

Copyright

This image is from Kovanen PE, J Biol Chem 2008 Jun 20;283(25):17362-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:138077

Associated Alleles

Symbol	Name
Tg(H2-K-DUSP5)21Wjl	transgene insertion 21, Warren J Leonard

Associated Genotypes

Allelic Composition	Genetic Background
Tg(H2-K-DUSP5)21Wjl/0	involves: C57BL/6J * CBA