Phenotype Image Detail

Image

Caption

Morphology of the trigeminal nerve in Cers2^{Gt(S16-4B1)Sor}/Cers2^{Gt(S16-4B1)Sor} mice. A and B, morphology of trigeminal nerve axons in wild-type (+/+) mice. Note the regular delineation between axons and myelin sheaths and the morphology of Schmidt-Lantermann incisures in axons of different caliber (white arrows). C-E, in Cers2^{Gt(S16-4B1)Sor}/Cers2^{Gt(S16-4B1)Sor} (gt/gt) axons, toluidine blue-stained material was found in irregular patches attached to the inner myelin surface of a fraction of the axons (black arrows), in some cases affecting or being in the direct vicinity of Schmidt-Lantermann incisures (white arrows in E). F-I, ultrastructurally, these patches correspond to accumulations of whorled material (black arrows in G and H), apparently being derived from focally delaminated inner myelin sheath wrappings (compare cross-sections of wild-type and mutant mice in F and G). The axon membrane, therefore, is focally indented. In obliquely or longitudinally cut axons, it becomes apparent that multiple focal lesions exist (black arrows in H), between which the axon membrane readapts to the inner myelin surface. In some cases, stacks of disarranged myelin obliquely traverse the entrie myelin sheath thickness in a course reminiscent of a Schmidt-Lantermann incisure with the characteristic outer and inner leaflets of compact myelin (OL and IL in I). Calibration bars, 10 um in A-E and 1 um in F-I.

Copyright

This image is from Imgrund S, J Biol Chem 2009 Nov 27;284(48):33549-60 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:156841

Associated Alleles

Symbol	Name
Cers2^Gt(S16-4B1)Sor	ceramide synthase 2; gene trap S16-4B1, Philippe Soriano

Associated Genotypes

Allelic Composition	Genetic Background
Cers2^Gt(S16-4B1)Sor/Cers2^Gt(S16-4B1)Sor	involves: 129S4/SvJaeSor * C57BL/6