Phenotype Image Detail

Image

Caption

Ultrastructural features of liver cells from Acox1^tm1Jkr/Acox1^tm1Jkr mice confirm the peroxisomal mosaicism in liver cells. A, an electron micrograph of liver cells from a 2-month-old Acox1^tm1Jkr/Acox1^tm1Jkr mouse shows a rare hepatocyte on the left with numerous peroxisomes and one on the right, which lacks morphologically distinct peroxisomes and contains abundant lipid droplets (L). B, these steatotic hepatocytes predominate during the first 2-3 months of age and contain few or no peroxisomes but show fat droplets (L). C and D are representative electron micrographs from 5-7 month old mutant liver. Spontaneous peroxisome proliferation is evident in the hepatocytes of older mice in cells without steatosis. A steatotic hepatocyte with lipid droplets (arrows) is seen in the right upper portion of panel C. These livers were processed for the localization of catalase by the alkaline diaminobenzidine medium.

Copyright

This image is from Fan CY, J Biol Chem 1996 Oct 4;271(40):24698-710 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:35794

Associated Alleles

Symbol	Name
Acox1^tm1Jkr	acyl-Coenzyme A oxidase 1, palmitoyl; targeted mutation 1, Janardan K Reddy

Associated Genotypes

Allelic Composition	Genetic Background
Acox1^tm1Jkr/Acox1^tm1Jkr	involves: 129P2/OlaHsd * C57BL/6J