Phenotype Image Detail

Image

Caption

Phenotypic comparison between Pkd2^tm1Gwu/Pkd2^tm1Gwu and Pkhd1^tm1Gwu/Pkhd1^tm1Gwu mice. A, gross phenotypes of Pkd2^tm1Gwu/Pkd2^tm1Gwu (Pkd^nf3/nf3) and Pkhd1^tm1Gwu/Pkhd1^tm1Gwu (Pkhd1^-/-) mice demonstrated growth retardation compared with wild-type (WT) littermates 2 weeks after birth (panel a). Severe dilatation of the common bile duct (arrow) was observed in Pkd2^tm1Gwu/Pkd2^tm1Gwu mice (panel b). The gross cystic phenotypes (arrows) were similar between 12 month old Pkd2^tm1Gwu/Pkd2^tm1Gwu kidneys (panel c) and 4 month old Pkhd1^tm1Gwu/Pkhd1^tm1Gwu kidneys (panel d). In the same pair of mice, similar gross cystic phenotypes and focal necrosis (arrows) were seen in the liver (panels e and f). B, microscopic phenotypes of Pkd2^tm1Gwu/Pkd2^tm1Gwu and Pkhd1^tm1Gwu/Pkhd1^tm1Gwu mice. In 12 month old wild-type mice, medullary tubules (panel a), cortical glomeruli (panel b), and the tubulointerstitial compartment (panel b) were normal. Similarly, liver (panel c) and pancreatic (panel d) sections exhibited normal histology in the same mouse. In 12 month old Pkd2^tm1Gwu/Pkd2^tm1Gwu mice, there was a focal dilatation of papillary collecting ducts and patchy dilatation of proximal tubules (panels e and f), as well as an increased expansion of Bowman's space (right arrow in panel f) in the renal cortex. These mice also showed dilated biliary ducts and central veins with lymphocyte infiltration/necrosis (panel g, arrows). There was also dilatation of both small and large pancreatic ducts (panel h, arrow). Tissue sections from 4 month old Pkhd1^tm1Gwu/Pkhd1^tm1Gwu mice, which correspond to panels e-h, are shown in panels i-l. Scale bars = 2 mm in A and 10 um in B.

Copyright

This image is from Kim I, J Biol Chem 2008 Nov 14;283(46):31559-66 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:143124

Associated Alleles

Symbol	Name
Pkd2^tm1Gwu	polycystin 2, transient receptor potential cation channel; targeted mutation 1, Guanqing Wu
Pkhd1^tm1Gwu	polycystic kidney and hepatic disease 1; targeted mutation 1, Guanqing Wu

Associated Genotypes

Allelic Composition	Genetic Background
Pkd2^tm1Gwu/Pkd2^tm1Gwu	involves: C57BL/6
Pkhd1^tm1Gwu/Pkhd1^tm1Gwu	Not Specified