Phenotype Image Detail

Image

Caption

A: Retinoid-depleted (retinoid-deficient diet) Dgat1^tm1Far/Dgat1^tm1Far (Dgat1^-/-) mice (n = 6) did not develop alopecia by 13 weeks of age, whereas chow-fed mutant mice (n = 5) had prominent alopecia by 13 weeks of age. B: In retinoid-depleted mutant mice, resumption of the retinoid-sufficient diet at age 13 weeks induced alopecia within 8 days (n = 3/group). C: mRNA levels of Crbpl were lower, and Crabpll trended lower in whole skin of mutant mice fed the retinoid-deficient diet than those fed the retinoid-sufficient diet (age 7.5-14 weeks, n = 2-6 mice/group). *, p<0.001; **, p<0.05 versus wild-type; #, p <0.05; t, p = 0.079 versus retinoid-sufficient diet. RD, retinoid-deficient; RS, retinoid-sufficient.

Copyright

This image is from Shih MY, J Biol Chem 2009 Feb 13;284(7):4292-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:147611

Associated Alleles

Symbol	Name
Dgat1^tm1Far	diacylglycerol O-acyltransferase 1; targeted mutation 1, Bob Farese

Associated Genotypes

Allelic Composition	Genetic Background
Dgat1^tm1Far/Dgat1^tm1Far	involves: 129S4/SvJae * C57BL/6J