Phenotype Image Detail

Image

Caption

A: Schematic of the first two postnatal hair cycles in Dgat1^tm1Far/Dgat1^tm1Far (Dgat1^-/-) and wild-type (Dgat1+/+) mice (P44, n = 6/genotype; P63, n = 5/genotype; n = 3/genotype at all other time points). A, anagen (black); C, catagen (black gradient); T, telogen (white). B: Precocious onset of second anagen in mutant mice. Mutant and wild-type mice were shaved on P51 and photographed at various time points thereafter. Precocious anagen onset is evident in mutant mice by the appearance of new hair at P63 and complete regrowth of hair by P76 ( n = 5/genotype). C: Retinoid deprivation modulates the onset of the second anagen phase in mutant mice. Schematic time line depicting the onset of the second postnatal anagen phase in five retinoid-depleted mutant mice compared with the average age of onset of second anagen in chow-fed mutant and wild-type mice. T, telogen (white bar); A, anagen (black bar). RD, retinoid-deficient; RS, retinoid-sufficient.

Copyright

This image is from Shih MY, J Biol Chem 2009 Feb 13;284(7):4292-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:147611

Associated Alleles

Symbol	Name
Dgat1^tm1Far	diacylglycerol O-acyltransferase 1; targeted mutation 1, Bob Farese

Associated Genotypes

Allelic Composition	Genetic Background
Dgat1^tm1Far/Dgat1^tm1Far	involves: 129S4/SvJae * C57BL/6J