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Caption | The ocular phenotype observed in Lmx1btm1Rjo/Lmx1btm1Rjo mice is observed during embryogenesis. Sections taken at E13.5 indicate no morphological differences between wild-type (+/+, a) and Lmx1btm1Rjo/Lmx1btm1Rjo (-/-, b) littermates. Extraocular muscles (eom, arrows) are present by E15.5 in wild-type (c) as well as mutant (d) mice. Areas boxed in (c) and (d) are enlarged in (e) and (f). At E15.5 (c-f), the first observable differences between wild-type (c,e) and mutant (d,f) occur in the cornea (c) and in the prospective iris (arrow). Mutant corneal stroma is less densely packed, and cells that are likely to contribute to iris and ciliary body stroma (arrow) are hypoplastic (f) in comparison to wild-type eyes (e). The asterisk indicates that mutant anterior chamber depth is affected as early as E15.5 (f). Scale bars = 100 um. | ||||
Copyright | This image is from Pressman CL, Genesis 2000 Jan;26(1):15-25, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:60307 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/27/2024 MGI 6.24 |
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