Phenotype Image Detail

Image

Caption

Analysis of collagen fibrillogenesis in corneas. Transmission electron microscopy illustrates the difference between wild-type corneal stroma (a) and Lmx1b^tm1Rjo/Lmx1b^tm1Rjo stroma (b) at 10,000x, Arrows in (a) indicate the orthogonal arrangement of collagen fibrils between keratocytes (k) in the wild-type. The asterisk in (b) indicates electron lucent space in mutant corneal stroma. The boxed areas in (a,b) represent sections examined at 50,000x in (c and d). Cross sections through collagen fibrils reveal that fibril diameter is larger in mutant corneas (d, arrow) than in wild-type corneas (c, arrow). (a,b) White scale bars = 500nm. (c,d) White scale bars = 100nm.

Copyright

This image is from Pressman CL, Genesis 2000 Jan;26(1):15-25, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:60307

Associated Alleles

Symbol	Name
Lmx1b^tm1Rjo	LIM homeobox transcription factor 1 beta; targeted mutation 1, Randy L Johnson

Associated Genotypes

Allelic Composition	Genetic Background
Lmx1b^tm1Rjo/Lmx1b^tm1Rjo	involves: 129 * C57BL/6