Phenotype Image Detail

Image

Caption

Histopathology of the wild-type and Ackr3^tm1Jgo/Ackr3^tm1Jgo mouse heart. (A) Macroscopy of 8-month old wild-type (+/+) and Ackr3^tm1Jgo/Ackr3^tm1Jgo (-/-) heart cut in sagittal plane. Left ventricular wall, septum and right ventricular wall are marked L, S, and R respectively. Microscopy of (B) myocytes of the wild-type heart and (E) a locus of degenerating myocytes in the mutant heart. Sections were stained with hematoxylin and eosin (HE). Scale bar represents 50 um. Sirius red staining of a (C) wild-type and (F) mutant heart. Scale bar represents 50 um. Red staining represents collagen disposition. Shown is a site of fibrosis in a mutant heart. Microscopy of (D) wild-type heart and (G) mutant heart with thrombus in the right atrium. Sections were stained with HE and the scale bar represents 500 um. Arrow indicates thrombus in the right atrium.

Copyright

This image is from Gerrits H, Genesis 2008 May;46(5):235-45, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:136246

Associated Alleles

Symbol	Name
Ackr3^tm1Jgo	atypical chemokine receptor 3; targeted mutation 1, Jan A Gossen

Associated Genotypes

Allelic Composition	Genetic Background
Ackr3^tm1Jgo/Ackr3^tm1Jgo	involves: 129S/SvEvBrd * C57BL/6