Phenotype Image Detail

Image

Caption

Skeleton morphology. Degenerative joint problems were developed in the knee (A), the ankle (C), and the temporomandibular joints (TMJ) (E) of 3-month old Errfi1^tm1.1Jwj/Errfi1^tm1.1Jwj ((Mig-6^-/-) mice, but not in the wild-type (WT) mice (B,D, and F). Arrows indicate the abnormal outgrowth of bony nodules on the defective joints. H&E staining shows that the rear limb joints of mutant mice have rough joint surfaces and narrowed joint spaces; multiple abnormal cysts filled with fibroblast-like cells were formed in the subchondrial areas (G). H&E staining of the wild-type joint exhibits normal structures (H).

Copyright

This image is from Jin N, Genesis 2007 Nov;45(11):716-21, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:129106

Associated Alleles

Symbol	Name
Errfi1^tm1.1Jwj	ERBB receptor feedback inhibitor 1; targeted mutation 1.1, Jae-Wook Jeong

Associated Genotypes

Allelic Composition	Genetic Background
Errfi1^tm1.1Jwj/Errfi1^tm1.1Jwj	involves: 129 * C57BL/6 * FVB/N * SJL