Phenotype Image Detail

Image

Caption

Radiographic analysis of joint abnormalities in Bmal1^tm1Bra/Bmal1^tm1Bra mice. Whole-body radiographs of wild-type (Mop3 +/+, a) and Bmal1^tm1Bra/Bmal1^tm1Bra (Mop3 -/-, b) mice at 35 weeks of age. c-f: High-resolution radiography of thoracic vertebrae. c: Wild-type mouse and (d) mutant mouse at 26 weeks. Distinguishing calcifications of ventral longitudinal ligament and at the region where the dorsal longitudinal ligament inserts into the vertebral bodies in mutant mice. (white arrows) were observed. e: Wild-type mouse at 35 weeks of age and (f) mutant at 35 weeks. Increased trabecular density corresponds to bridging ankylosis in all directions from the vertebral body and includes calcification of vertebral disk and distortion of the anatomy of the costal chondral attachment (white arrows).

Copyright

This image is from Bunger MK, Genesis 2005 Mar;41(3):122-32, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:97108

Associated Alleles

Symbol	Name
Bmal1^tm1Bra	basic helix-loop-helix ARNT like 1; targeted mutation 1, Christopher A Bradfield

Associated Genotypes

Allelic Composition	Genetic Background
Bmal1^tm1Bra/Bmal1^tm1Bra	B6.129-Bmal1^tm1Bra