Phenotype Image Detail

Image

Caption

A: Histology of seminiferous tubules of juvenile Hsf2^tm1Miv/Hsf2^tm1Miv (Hsf2^-/-, 7 and 18 day-old) and Hsf1^tm1Miv/Hsf1^tm1Miv Hsf2^tm1Miv/Hsf2^tm1Miv (hsf1^-/- hsf2^-/-, 18 day-old) mice compared to wild-type (+/+) counterparts. Paraffin-embedded sections were stained with hematoxylin and eosin. x630. B: Quantitative representation of the mean number of spermatogonia or spermatocytes per Sertoli cells in the randomly sectioned seminiferous tubules from juvenile wild-type and mutant mice. Sertoli, spermatogonia, and spermatocytes were counted using their characteristic morphology under light microscopy after H&E staining. Error bars represent the standard deviation of the means. Significant changes between groups are indicated as determined by Student's t-test.

Copyright

This image is from Wang G, Genesis 2004 Feb;38(2):66-80, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:88035

Associated Alleles

Symbol	Name
Hsf1^tm1Miv	heat shock factor 1; targeted mutation 1, Nahid F Mivechi
Hsf2^tm1Miv	heat shock factor 2; targeted mutation 1, Nahid F Mivechi

Associated Genotypes

Allelic Composition	Genetic Background
Hsf2^tm1Miv/Hsf2^tm1Miv	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Hsf1^tm1Miv/Hsf1^tm1Miv Hsf2^tm1Miv/Hsf2^tm1Miv	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6