About   Help   FAQ
Phenotype Image Detail
Image
Caption Morphological and histological abnormalities in Ryr1tm1.1Dhm/Ryr1+ mice. (A) Twelve-month old wild-type (WT) and (B) Ryr1tm1.1Dhm/Ryr1+ (IT/+) female littermates. The mutant mouse exhibits dorsal kyphosis and hind limb paresis. Note the flattend posture and outstretched hind limbs that fail to lift the hindquarters. (C-G) NADH-TR-stained longitudinal sections of mutant soleus myofibers from 12-month old (C-E) and 20-month-old (F and G) mice showing minicores and cores. In C-E, arrows show minicores occupying eccentric (C), peripheral (E), and central (D) postiions. In D, the minicore (arrow) shows intense peripheral staining revealing the distorted cross-striation of focally contracted myofibrils. In F and G, the arrows show cores extending longitundinally over multiple sarcomeres. (Scale bars, 10 mm).
Copyright This image is from Zvaritch E, Proc Natl Acad Sci U S A 2009 Dec 3;():. Copyright 2009 National Academy of Sciences, U.S.A. J:155825
Associated
Alleles
Symbol Name
Ryr1tm1.1Dhm ryanodine receptor 1, skeletal muscle; targeted mutation 1.1, David H MacLennan
Associated
Genotypes
Allelic Composition Genetic Background
Ryr1tm1.1Dhm/Ryr1+ involves: 129S2/SvPasCrl * 129S6/SvEvTac

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory