Phenotype Image Detail

Image

Caption

Ultrastructural abnormalities in longitudinal sections of a type 1 fiber from an 18 month old Ryr1^tm1.1Dhm/Ryr1⁺ mouse. (A) Core-like lesions with rods streaming the length of a full-width myofiber. (B) An unstructured core area with rods, which is contiguous with an area of relatively well-structured myofibrils, illustrating the origin of a "cornucopia" of rods in the Z-line. (C) A higher magnification of a rod from B, revealing its lattice-like structure. (Scale bars, 5 um (A), 2 um (B), and 1 um C).

Copyright

This image is from Zvaritch E, Proc Natl Acad Sci U S A 2009 Dec 3;():. Copyright 2009 National Academy of Sciences, U.S.A. J:155825

Associated Alleles

Symbol	Name
Ryr1^tm1.1Dhm	ryanodine receptor 1, skeletal muscle; targeted mutation 1.1, David H MacLennan

Associated Genotypes

Allelic Composition	Genetic Background
Ryr1^tm1.1Dhm/Ryr1^+	involves: 129S2/SvPasCrl * 129S6/SvEvTac