Phenotype Image Detail

Image

Caption

Mapk6^tm1Melo/Mapk6^tm1Melo mice display neonatal lethality. (A) Representative photograph of a cyanotic Mapk6^tm1Melo/Mapk6^tm1Melo pup (-/-) and wild-type (+/+) littermate immediately after birth. (B) Lungs isolated from a wild-type newborn are well inflated as compared to those of a mutant mouse. (C) Mutant newborns surviving acute respiratory failure lack milk (*) in their stomach. Note the carpoptosis (arrow) in the mutant mouse. (D) Body weight distribution of wild-type, heterozygous and mutant newborns after birth. The mean body weight is indicated for each genotype.

Copyright

This image is from Klinger S, Proc Natl Acad Sci U S A 2009 Sep 29;106(39):16710-5. Copyright 2009 National Academy of Sciences, U.S.A. J:153218

Associated Alleles

Symbol	Name
Mapk6^tm1Melo	mitogen-activated protein kinase 6; targeted mutation 1, Sylvain Meloche

Associated Genotypes

Allelic Composition	Genetic Background
Mapk6^tm1Melo/Mapk6^tm1Melo	involves: 129S1/Sv * 129X1/SvJ * C57BL/6