Phenotype Image Detail

Image

Caption

Mouse heads were embedded in paraffin, sectioned and stained with hematoxylin and eosin. (A) At E14.5, the palatal processes are still in a ventrical position. There is no obvious difference between wild-type (+/+) and Bnc2^{Gt(pU21)18Imeg}/Bnc2^{Gt(pU21)18Imeg} (-/-) embryos. (B) Anterior section at E15.5. Processes have begun to elevate in both mutant and wild-type. (C) E16.5 embryos. Palatal processes have elevated and fused in the wild-type. In the mutant embryo, processes have elevated but have failed to fuse because of insufficient growth toward the midline, thus causing cleft palate. (D) At P0, the wild-type mouse shows normal fused palate, whereas a cleft palate is evident in the mutant. Head and tongue of the mutant are smaller than those of the wild-type. Asterisks indicate cleft palate.

Copyright

This image is from Vanhoutteghem A, Proc Natl Acad Sci U S A 2009 Aug 25;106(34):14432-7. Copyright 2009 National Academy of Sciences, U.S.A. J:151992

Associated Alleles

Symbol	Name
Bnc2^Gt(pU21)18Imeg	basonuclin zinc finger protein 2; gene trap 18, Institute of Molecular Embryology and Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Bnc2^Gt(pU21)18Imeg/Bnc2^Gt(pU21)18Imeg	involves: C57BL/6 * CBA