Phenotype Image Detail

Image

Caption

Histology of Pi4k2a^{Gt(AK0094)Wtsi}/Pi4k2a^{Gt(AK0094)Wtsi} spinal cord. (A and B) Overviews of the structure of thoracic spinal cord from wild-type (WT, A) and Pi4k2a^{Gt(AK0094)Wtsi}/Pi4k2a^{Gt(AK0094)Wtsi} (KO, B) mice. The white matter defects are clearly evident in ascending and descending tracts of mutant mice (D,F,H and J) when compared with wild-type (C,E,G and I). (C-J) Shown are higher magnification images of the sections shown in A and B. (Magnification: A and B, 30x linear magnification; C-J, 110x linear magnification).

Copyright

This image is from Simons JP, Proc Natl Acad Sci U S A 2009 Jul 14;106(28):11535-9. Copyright 2009 National Academy of Sciences, U.S.A. J:150794

Associated Alleles

Symbol	Name
Pi4k2a^Gt(AK0094)Wtsi	phosphatidylinositol 4-kinase type 2 alpha; gene trap AK0094, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Pi4k2a^Gt(AK0094)Wtsi/Pi4k2a^Gt(AK0094)Wtsi	involves: 129P2/OlaHsd * BALB/c