Phenotype Image Detail

Image

Caption

(A) The weights of both liver and spleen from Lgmn^tm1Ihn/Lgmn^tm1Ihn mice (open bar) were significantly higher then those of age-matched wild-type controls (filled bar). *, P<0.05; ***, P<0.001, n=8. (B) Age-dependent increase of spleen weight in mutant mice. Homozygous mutant mice (filled circles) and Lgmn^tm1Ihn/Lgmn⁺ control (open circles) of various ages as indicated were euthanized and the spleens were weighed (3 month-old: +/-, n=6, -/-, n=6; 6 month-old: +/-, n=6, -/-, n=6; 9 month-old: +/-, n=3, -/-, n=10; 12 month-old: +/-, n=4, -/-, n=3; 15 month-old: +/-, n=3, -/-, n=10; 18 month-old: +/-, n=6, -/-, n=8). (C) H&E staining of the spleen from both heterozygous (+/-) and homozygous mutant (-/-). (Scale bar, 500 um). (D) H&E staining of homozygous mutant spleen showing numerous hemophagocytes. (Scale bar, 500 um). (E) Giemsa staining of splenocytes from homozygous mutant mice showing immature myeloid lineage cells.

Copyright

This image is from Chan CB, Proc Natl Acad Sci U S A 2009 Jan 13;106(2):468-73. Copyright 2009 National Academy of Sciences, U.S.A. J:143886

Associated Alleles

Symbol	Name
Lgmn^tm1Ihn	legumain; targeted mutation 1, Ikuko Hara-Nishimura

Associated Genotypes

Allelic Composition	Genetic Background
Lgmn^tm1Ihn/Lgmn^tm1Ihn	involves: 129P2/OlaHsd * C57BL/6