Phenotype Image Detail

Image

Caption

(A) Loss of hind limb extension reflex in Ltn1^lister/Ltn1^lister mice manifested by hind limb clenching when lifted by the tail. (B) Motor function of homozygous mutants (white bars, n=8) compared with Ltn1^lister/Ltn1⁺ (gray bars, n=12) and wild-type littermates (black bars, n=12) measured by accelerated rotarod test. Wild-type versus homozygous mutant mice: P < 0.0005 at 3 weeks of age, P < 0.02 at 6 weeks of age, P < 0.0005 at 9 weeks of age. Heterozygous (n=12) versus wild-type mice (n=10): P=0.127 at 63 weeks of age. (C) Survival curve of homozygous mutants (white circles, n=25) compared with heterozygous and wild-type littermates (black circles, n=25). (D) Body weight curve for wild-type (black circles, n=14), heterozygotes (gray circles, n=32) and homozygous mutant mice (white circles, n=14).

Copyright

This image is from Chu J, Proc Natl Acad Sci U S A 2009 Feb 17;106(7):2097-103. Copyright 2009 National Academy of Sciences, U.S.A. J:146493

Associated Alleles

Symbol	Name
Ltn1^lister	listerin E3 ubiquitin protein ligase 1; lister

Associated Genotypes

Allelic Composition	Genetic Background
Ltn1^lister/Ltn1^lister	C57BL/6-Ltn1^lister