Phenotype Image Detail

Image

Caption

(A and B) Toluidine blue staining of white matter of spinal cord from wild-type and Ltn1^lister/Ltn1^lister mice, respectively. Arrowhead indicates a degenerating axon. (C and D) TEM images of distal femoral nerve branches of wild-type and mutants, respectively. (E and F) H&E staining of hind-leg quadriceps skeletal muscles from wild-type and mutant mice, respectively. Arrow indicates a centrally nucleated muscle fiber. (G) Comparison of number of motor neurons >25 um in diameter in lumbar spinal cord between +/+ (black bar, n=5) and mutant (gray bars, n=7) mice at symptom onset (P = 0.639) and terminal stage (P<0.05). (H) Number of axons counted from cross sections of motor and sensory L5 roots in mutant and wild-type littermates at different stages (n=3-5 each genotype per age group). Wild-type versus mutant mice at symptom onset for motor root (P=0.741) and sensory root (P=0.135), at terminal stage for motor root (P<0.05) and sensory root (P<0.01). (I and J) Distribution of axon diameters from the entire motor and sensory roots of terminal-staged mutant (gray circles) versus wild-type (black circles).

Copyright

This image is from Chu J, Proc Natl Acad Sci U S A 2009 Feb 17;106(7):2097-103. Copyright 2009 National Academy of Sciences, U.S.A. J:146493

Associated Alleles

Symbol	Name
Ltn1^lister	listerin E3 ubiquitin protein ligase 1; lister

Associated Genotypes

Allelic Composition	Genetic Background
Ltn1^lister/Ltn1^lister	C57BL/6-Ltn1^lister