Phenotype Image Detail

Image

Caption

(A and B) TEM images of neurons (arrows) in the ventral side of lumbar spinal cord from wild-type (+/+) and Ltn1^lister/Ltn1^lister, respectively. Arrowheads indicate abnormal axons in B. (C and D) TEM images of axons in white matter of the ventral lateral side of lumbar spinal cord from wild-type and mutant, respectively. Arrowheads indicate two of the abnormal/degenerating axons. (E and F) Vacuolated mitochondria (M) are found in postsynaptic profiles (*), likely dendrites of mutant mouse (F). Compare this to the wild-type mouse (E). Note synapses or presynaptic profiles appear to be normal. Arrowhead indicates a damaged axoplasm surrounded by myelin sheath.

Copyright

This image is from Chu J, Proc Natl Acad Sci U S A 2009 Feb 17;106(7):2097-103. Copyright 2009 National Academy of Sciences, U.S.A. J:146493

Associated Alleles

Symbol	Name
Ltn1^lister	listerin E3 ubiquitin protein ligase 1; lister

Associated Genotypes

Allelic Composition	Genetic Background
Ltn1^lister/Ltn1^lister	C57BL/6-Ltn1^lister