Phenotype Image Detail

Image

Caption

Phenotype of Myh11^tm2Peri/Myh11^tm2Peri mice. (A) (Upper) Comparison of bladder (square 1), alimentary tract (square 2) including stomach (square 3), and the kidney (square 4) in wild-type (SM2^+/+) and Myh11^tm2Peri/Myh11^tm2Peri (SM2^-/-) mice (20 days). Note the retention of urine in the renal pelvis of the mutant kidney. (Lower) Development end-stage hydronephrosis with severe retention of urine in the renal pelvis in 25-day mutant mice and kidneys in age-matched wild-type mice. (B) (Upper) Comparison of neonatal and peri-mortal mutant with age-matched wild-type bladders. (Lower) Histology (40x) of peri-mortal mutant and age-matched wild-type bladders.

Copyright

This image is from Chi M, Proc Natl Acad Sci U S A 2008 Nov 25;105(47):18614-8. Copyright 2008 National Academy of Sciences, U.S.A. J:142230

Associated Alleles

Symbol	Name
Myh11^tm2Peri	myosin, heavy polypeptide 11, smooth muscle; targeted mutation 2, Muthu Periasamy

Associated Genotypes

Allelic Composition	Genetic Background
Myh11^tm2Peri/Myh11^tm2Peri	involves: 129 * C57BL/6