Phenotype Image Detail

Image

Caption

Cdsn deficiency results in stratum corneum detachment because of defective desmosome formation. (A) Desmosomal dissociation in Cdsn^tm1Mmat/Cdsn^tm1Mmat (-/-) mouse epidermis assessed by using transmission electron microscopy. (Scale bar: 10 um). (B) In contrast to wild-type (+/+, left) mice, desmosomal structures were very few and were confined to the lower stratum corneum in mutant mice (right). (Scale bars: 2 um).

Copyright

This image is from Matsumoto M, Proc Natl Acad Sci U S A 2008 May 6;105(18):6720-4. Copyright 2008 National Academy of Sciences, U.S.A. J:134613

Associated Alleles

Symbol	Name
Cdsn^tm1Mmat	corneodesmosin; targeted mutation 1, Mitsuru Matsumoto

Associated Genotypes

Allelic Composition	Genetic Background
Cdsn^tm1Mmat/Cdsn^tm1Mmat	involves: C57BL/6 * CBA