Phenotype Image Detail

Image

Caption

Rapid hair loss due to the defective holding of hair shafts by Cdsn-deficient inner root sheath (IRS). Hair follicles from grafted Cdsn^tm1Mmat/Cdsn^tm1Mmat skin (-/-, lower) demonstrated abnormal cystic dilatation of follicular infundibulum (arrowheads) and/or cystic dilatation of infundibulum filled with keratinized cells (arrows). Additionally, infundibular epithelium (asterisks) is thickened in grafted mutant skin compared with that from grafted wild-type (+/+, upper) skin. Note that grafted control skin contains hairs at a catagen phase, in which the formation of club hair is observed (upper, white arrows). (Scale bars: 100 um).

Copyright

This image is from Matsumoto M, Proc Natl Acad Sci U S A 2008 May 6;105(18):6720-4. Copyright 2008 National Academy of Sciences, U.S.A. J:134613

Associated Alleles

Symbol	Name
Cdsn^tm1Mmat	corneodesmosin; targeted mutation 1, Mitsuru Matsumoto

Associated Genotypes

Allelic Composition	Genetic Background
Cdsn^tm1Mmat/Cdsn^tm1Mmat	involves: C57BL/6 * CBA