Phenotype Image Detail

Image

Caption

Peripheral nerve pathology in Sbf2^{Gt(RRF511)Byg}/Sbf2^{Gt(RRF511)Byg} (Mtmr13-/-) mice has an early onset and worsens with age. Mice were analyzed at postnatal days 14 and 26 (P14 and P28) and 2,4,7 and 14 months (mo). Semithin (0.5 um) or ultrathin (70 nm) transverse sections of mid-sciatic nerves were examined by light microscopy or EM. (A) Myelin infoldings and outfoldings (arrowheads in mutant images) are detected in P14 mutant mice and increase in frequency with age. (B) Quantification of progression of dysmyelination in mutant mice. Either two or three mutant mice were analyzed at each time point. The percentage of abnormal fibers (fibers with one or more myelin outfolds or infolds) is presented as mean +/- SEM. *, for the 1-and 2-month means, the SEMs were 0.34 and 0.43, respectively. (Scale bar: 20 mm.)

Copyright

This image is from Robinson FL, Proc Natl Acad Sci U S A 2008 Mar 25;105(12):4916-21. Copyright 2008 National Academy of Sciences, U.S.A. J:133391

Associated Alleles

Symbol	Name
Sbf2^Gt(RRF511)Byg	SET binding factor 2; gene trap RRF511, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Sbf2^Gt(RRF511)Byg/Sbf2^Gt(RRF511)Byg	involves: 129P2/OlaHsd * C57BL/6