Phenotype Image Detail

Image

Caption

Gross morphology and histological abnormalities in Ryr1^tm1.1Dhm/Ryr1^tm1.1Dhm neonates. Gross lateral view of wild-type (A) and Ryr1^tm1.1Dhm/Ryr1^tm1.1Dhm (B) littermates. Note the smaller size, the curved embryonic posture, and the transparent skin of the mutant pup (B). (C-F) HE stained tissue sections. (C and D) Sections through the skin layers at the cervical region. Arrow shows the dermis. BF, brown fat; SM, skeletal muscle. Magnification x20. (E and F) Sections of hind limb skeletal muscle. Magnification x20. (G and H) Electron micrographs of myotubes from E18 fetal diaphragm. Arrowheads show myofibril branchings in mutant myotubes (H). Triads, indicated with arrows, are more frequent in wild-type muscles (G).

Copyright

This image is from Zvaritch E, Proc Natl Acad Sci U S A 2007 Nov 20;104(47):18537-42. Copyright 2007 National Academy of Sciences, U.S.A. J:127629

Associated Alleles

Symbol	Name
Ryr1^tm1.1Dhm	ryanodine receptor 1, skeletal muscle; targeted mutation 1.1, David H MacLennan

Associated Genotypes

Allelic Composition	Genetic Background
Ryr1^tm1.1Dhm/Ryr1^tm1.1Dhm	involves: 129S6/SvEvTac * 129X1/SvJ