Phenotype Image Detail

Image

Caption

(A-C) Scanning electron micrographs of a normal appearing E11.5 Itpk1^{Gt(DTM066)Byg}/Itpk1^{Gt(DTM066)Byg} mouse (A) and two littermates (B and C) with varying degrees of exencephaly (arrowheads). The inset in panel C shows another view of the open neural tube. (D) Xgal-stained E10.5 mutant with both exencephaly (arrowhead) and spina bofida (arrows). The dashed line indicates the orientation of the tissue section shown in the inset. The asterisk highlights the open neural tube. (E) Nascent myelomeningocele (arrowheads) in an E11.5 mutant. (F and G) Dashed lines indicate the orientation of tissue sections through the intact neural tube (F) and open neural tube (G, asterisk). (H and I) E14.5 mouse skeletons stained with alcian blue and alizarin red to visualize cartilage and bone. The inset in panel H shows two littermates, one of which has kyphoscoliosis (arrowhead). Higher magnification views of this embryo are shown in panels H and I. Note the presence of malformed ribs (arrowheads in I). Abbreviations: drg, dorsal root ganglia; hl, hind limb; lb, limb bud; mc, myelocele; ntc, notochord.

Copyright

This image is from Wilson MP, Proc Natl Acad Sci U S A 2009 Jun 16;106(24):9831-5. Copyright 2009 National Academy of Sciences, U.S.A. J:150075

Associated Alleles

Symbol	Name
Itpk1^Gt(DTM066)Byg	inositol 1,3,4-triphosphate 5/6 kinase; gene trap DTM066, BayGenomics