Phenotype Image Detail

Image

Caption

(A-D) Scanning electron micrographs of stereocilia from 6 week old wild-type (Actg1^+/+, A,B) and 6 week old Actg1^tm1.1Erv/Actg1^tm1.1Erv (Actg1^-/-, C,D) mice. (E-H) Scanning electron microscopy images of OHC (outer hair cell) stereocilia from 16 week old wild-type (E,F) and mutant (G,H) mice. There is a loss of individual stereocilia from all three rows of OHC hair bundle form mutant mice. Images are from the middle turn of the cochlea. (I) Box and whisker plot (whiskers, maximum and minimum; box, 5^th-95^th percentile; line, mean) of the number of individual stereocilia in individual OHC bundles from wild-type or mutant mice at 6 and 16 weeks of age, *P<0.005. (J-K) Enlargements of image in (H) with arrows, indicating missing and shortened stereocilia. Scale bars A,C,E and G, 5um; B,D,F,H,J and K, 1um.

Copyright

This image is from Belyantseva IA, Proc Natl Acad Sci U S A 2009 Jun 16;106(24):9703-8. Copyright 2009 National Academy of Sciences, U.S.A. J:150067

Associated Alleles

Symbol	Name
Actg1^tm1.1Erv	actin, gamma, cytoplasmic 1; targeted mutation 1.1, James M Ervasti