Phenotype Image Detail

Image

Caption

Representative photographs of 15 day old FVB/N Tph2^tm1Bdr/Tph2^tm1Bdr (A) and 21 day old C57BL/6 Tph2^tm1Bdr/Tph2^tm1Bdr (B) mice. On both panels: Left, mutant mouse; right, wild-type mouse from the same litter. Body weight (BW) development (mixed genetic background) (C) and survival (C57BL/6 genetic background) (D) of mutant mice. Red line, mutant; blue line, wild-type mice. (E) IGF1 concentration in the serum of mutant mice (FVB/N-F4 genetic background) at different ages. Filled bars, mutant; open bars, wild-type mice. *, P<0.05; **, P<0.01; and ***, P<0.001 (Student's t test); and [?], P<0.0001 (Logrank test) mutant vs. age-matched wild-type mice; ^#, P<0.05 (Student's t st) 4 month old wild-type vs. mutant mice.

Copyright

This image is from Alenina N, Proc Natl Acad Sci U S A 2009 Jun 23;106(25):10332-7. Copyright 2009 National Academy of Sciences, U.S.A. J:150042

Associated Alleles

Symbol	Name
Tph2^tm1Bdr	tryptophan hydroxylase 2; targeted mutation 1, Michael Bader