Phenotype Image Detail

Image

Caption

Cardiac defects and aortic arch disorganization in Baz1b^tm1Ska/Baz1b⁺ and Baz1b^tm1Ska/Baz1b^tm1Ska embryos. (A) Mutant (heterozygous and homozygous) mice exhibited severe heart defects. Coronal sections of typical dilation of both ventricles of mutant mice and Eln^tm1Dyl/Eln^tm1Dyl (elastin-/-) mice at P0 are shown. Left atrium, left ventricle, right atrium, and right ventricle are indicated by la, lv, ra, and rv, respectively. Arrow indicates atrial septal defect (ASD); arrow head shows ventricular septal defect (VSD). (B) Heart defects in mutant mice were evident at E9.5. Sagittal sections of the embryo of each genotype are shown. Atrial chamber (a), left ventricle (lv), and right ventricle (rv) are shown. (C) Aortic arch defects of mutant mice. Stereomicroscopic images are shown. Aorta (ao), pulmonary artery (pa), and coarctation of the aorta (arrow) are indicated. (D) The fourth aortic arch artery of mutant mice at E10.5 was hypoplastic. Aortic arch arteries were visualized by ink injection. 3, 4, and 6 indicate the number of aortic arch arteries.

Copyright

This image is from Yoshimura K, Proc Natl Acad Sci U S A 2009 Jun 9;106(23):9280-5. Copyright 2009 National Academy of Sciences, U.S.A. J:149990

Associated Alleles

Symbol	Name
Baz1b^tm1Ska	bromodomain adjacent to zinc finger domain, 1B; targeted mutation 1, Shigeaki Kato

Associated Genotypes

Allelic Composition	Genetic Background
Baz1b^tm1Ska/Baz1b^tm1Ska	involves: C57BL/6 * CBA
Baz1b^tm1Ska/Baz1b^+	involves: C57BL/6 * CBA